|
|
| 学術論文 水素分子の媒体毎のまとめ |
培養細胞への水素分子の効果
水素ガスの吸引効果
水素水の飲用効果
水素生理的食塩水の効果
水素を含む点眼薬の効果
腸内細菌の水素の効果 |
培養細胞への水素分子の効果  |
| (1) Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata
K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic
antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med,
2007; 13: 688-694. |
| (2) Kikkawa YS, Nakagawa T, Horie RT, Ito J. Hydrogen protects auditory hair cells from free radicals. Neuroreport. 2009;20(7):689-694. |
| 水素ガスの吸引効果 |
| (1) Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata
K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic
antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med,
2007; 13: 688-694. |
| (2) Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation
of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion
through reducing oxidative stress. Biochem Biophys Res Commun, 2007; 361:
670-674. |
| (3) Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo
J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda
K. Inhalation of hydrogen gas reduces infarct size in the rat model of
myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun, 2008,373(1):30-35．. |
| (4) Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 2008; 8(10):2015-2024． |
| (5) Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu
W, Tao H, Li R. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia
rat model. Neurosci lett 2008,441(2):167-172． |
| (6) Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen
alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without
compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009;
64(4): 753-761. |
| (7) Matchett GA, Fathali N, Hasegawa Y, Jadhav V, Ostrowski RP, Martin RD, Dorotta IR, Sun X, Zhang JH. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.Brain Res. 2009; 1259:90-97. |
(8) Liu C, Cui JG, Sun Q, Cai JM. Hydrogen therapy may be an effective
and specific novel treatment for acute radiation syndrome. Medical Hypotheses.
In press
|
(9) Nakao A, Kaczorowski DJ, Wang Y, Cardinal JS, Buchholz BM, Sugimoto
R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR. Amelioration of rat
cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon
monoxide, or both. J Heart Lung Transplant. 2009 Dec 23. [Epub ahead of
print]
|
| (10) Positive effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G. Shock. 2009 Dec 7. [Epub ahead of print] |
| 水素水の飲用効果 |
| (1) Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki
J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T. Supplementation
of hydrogen-rich water improves lipid and glucose metabolism in patients
with type 2 diabetes or impaired glucose tolerance, Nutr. Res, 2008; 28:137-143． |
| (2) Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 2009; 34(2):501-508. |
| (3) Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi
R, Fukui M, Hasegawa G, Nakamura N, Fujinawa H, Mori T, Ohta M, Obayashi
H, Maruyama N, Ishigami A. Hydrogen-rich pure water prevents superoxide
formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.
Biochem Biophys Res Commun, 2008; 375(3): 346-350. |
(4) Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S. Consumption
of hydrogen water prevents atherosclerosis in apolipoprotein E knockout
mice. Biochem Biophys Res Commun, 2008, 377(4):1195-1198.
|
(5) Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa
S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is
protective against 6-hydroxydopamine-induced nigrostriatal degeneration
in a rat model of Parkinson’s disease. Neurosci Lett. 2009; 453(2): 81-85..
|
| (6) Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen
alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without
compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009;
64(4): 753-761. |
| (7) Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi
K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda
M. Hydrogen in drinking water reduces dopaminergic neuronal loss in the
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's
disease. PLoS One. 2009 Sep 30;4(9):e7247. |
| (8) Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A. Oral administration of hydrogen water prevents chronic allograft nephropathy in rat renal transplantation. Kidney Int. 2010; 77(2):101-109. |
| (9) Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa
Y, Ito M. Molecular hydrogen suppresses FceRI-mediated signal transduction
and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651-656. |
| (10) Nakao A, Toyoda Y, Sharma P, Evans M, Guthre N. Effectiveness of hydrogen
rich water on antioxidant status of subjects with potential metabolic syndtrome---
An open label pilot study. J Clin Biochem Nutr. 2010; 46; 1-10. |
| 水素生理的食塩水の効果 |
| (1) Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, Luo X, Sun X. Neuroprotective
effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain
Res. 2009; 1256: 129-137. |
| (2) Zheng XF, Mao YF, Cai JM, Li YH, Liu WW, Sun PL, Zhang JH, Sun XJ,
Yuan.HB Hydrogen-Rich Saline Protect s against Intestinal Ischemia/Reperfusion
Injury in Rats. Free Radical Res. 2009; 43(5):478-484. |
| (3) Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun.2009; 381(4):602-605. |
| (4) Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y. Zhang JH, Denoblec PJ, Tao HY,
Sun XJ. Hydrogen-rich saline protects myocardium against ischemia/reperfusion
injury in rats Exp Biol Med. 2009; 234 (10): 1212-1219. |
| (5) Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y, Yan RL, Su N, Ruan CP, Sun XJ, Wang Q. The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res. 2009 Aug 27. [Epub ahead of print] |
| 水素を含む点眼薬の効果 |
| (1) Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi
H, Ohta S, Ohsawa I. Protection of the retina by rapid diffusion of hydrogen:
administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion
injury. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):487-92. |
| 腸内細菌の水素の効果 |
(1) Shimouchi A, Nose K, Yamaguchi M, Ishiguro H, Kondo T. Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk. Biomarker Insights 2009:4 27-32.
|
| (2) Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K. Are the
effects of α-glucosidase inhibitors on cardiovascular events related to
elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett.
2009 ; 583(13):2157-2159. |
| (3) Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T.
Hydrogen from intestinal bacteria is protective for Concanavalin A-induced
hepatitis. Biochem Biophys Res Commun. 2009; 386(2):316-321. |
| (4) Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009 Aug 14;386(1):11-5. 2009; 386(1):11-15. |
| (5) Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T. Effect of dietary
turmeric on breath hydrogen. Dig Dis Sci. 2009; 54(8): 1725-1729. |
|
|
|
|
|
